Background: Dengue mosquito borne viral infection consisting of four serotypes has been increasing morbidity and mortality to steady rise in India for more than decade. Lack of specific treatment caused significant challenges to the health system in the management of fatal cases. The clinical spectrum of dengue, caused by any of the four serotypes of DENV, ranges from mild self-limiting dengue fever to severe forms of dengue such as hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Objective: To study and analyze natural anti-viral therapy (Cissampelos pareira mix) efficacy against dengue virus using PET CT as biomarker for the treatment efficacy. Methodology: 31 patients sample size; 18 patients serologically positive for dengue were analyzed prospectively. 3 patients with negative serology test were excluded from the study; 10 patients were assigned to control group. All positive serotype patients were analyzed using the NS1 antigen test; serotype grouping was also performed for all 18 patients. Before and after 2 weeks of use of natural antiviral (CP mix) therapy, followed up by PET CT. Ultrasound (n=18) and CXR (n=18) were performed as standard screening protocol for all 18 patients to rule out radiological abnormality. Other Radiological investigations were also used for screening ( CT ABD n=2, MR Brain=3 & CT chest n=4) for a few patients that had more severe symptoms after USG & CXR as an additional test before PET CT to avoid false positive results. Hematology study (n=8) was also performed in a few patients that had more severe symptoms. Results: data descriptive statistics frequency analysis was applied for analysis of PET CT of 18 patients. Percentage analysis was Chi- Square test was applied to test the significance of the categorical data. Patients were grouped into primary (n=8) and secondary (n=10) groups based on the clinical manifestation. Conclusion: compared to the current extensive use of PET CT in oncological imaging, infection monitoring and treatment efficacy, it will be a big breakthrough challenge, future prospects for infection imaging and treatment efficacy monitoring.
Keywords: 18F-FDG PET/CT; dengue DENV SEROTYPES: Antiviral (Cissampelos pareira CP mix) therapy, vaccines, future prospects.