Julius Vidikas1, Evelina Gudavičiūtė², Matas Kalinauskas²
1Lithuanian research center of health sciences
² Faculty of Medicine, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009 Kaunas, Lithuania
Thrombophilia, or hypercoagulable state, can cause various thrombotic events. It occurs due to inherited and/or acquired factors. Inherited risk factors, such as factor V Leiden, antithrombin, prothrombin, protein S and C mutations, have been associated with increased presence of venous thrombosis and some suggest an increased arterial thrombosis incidence as well. Acquired risk factors are found more often than inherited. The most prominent acquired risk factors include atrial fibrillation, malignancy, sepsis, obesity, diabetes mellitus, antiphospholipid syndrome and COVID-19 infection. All of these risk factors alone can cause thrombotic events, but most of the time thrombosis occurs due to multifactorial interaction of various established risk factors and patients’ overall well-being. With this article we present a case report of intracardial thrombosis in a patient with atrial fibrillation and a brief literature review of the causes of hypercoagulability.
Keywords: Thrombophilia, thrombosis, tomography.